Introduction to Drug-Receptor interaction
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Receptors: protein molecules including enzymes, transporters and ion channels where a ligand (specific endogenous neurotransmitter/hormone or an external pharmacological agent (drug)) binds to, resulting in a cellular response.
- Unique Exception: Orphan Receptors are receptors for which the ligand remains unknown.
- Reminder: Ligand is an ion or molecule that forms a complex with a biomolecule to serve a specific biological purpose
Examples of Endogenous Ligands:
- Acetylcholine [Ach]
- Acetylcholine [EPI]
- Acetylcholine [NE]
